The nearest international airport is in Guayaquil. From there, you can take a taxi or a bus to Ayampe.
Take a bus either to Olon or Montanita. It is the CLP bus company (large brown/maroon buses) direct from the Guayaquil Bus Terminal.
Take a green Manglaralto bus heading north. Ask the bus to stop at Ayampe. Ayampe is approximately 25 minutes away. Taxis from Montanita or Olon are around $15.
Take the Reina Del Camino Bus directly to Puerto Lopez.
Take a green Manglaralto bus heading south. Ask the bus to stop at Ayampe. Ayampe is approximately 15 minutes away. Taxis from Puerto Lopez are $5.
The bus will let you off on the E15 by a small store. It is a five minute walk to La Casa from here. Walk straight towards the ocean. At the end of the road, La Casa is the large white three-story building directly on the corner.